The Metabolic Stack: Semaglutide + Ipamorelin/CJC-1295
The advanced body recomposition stack combining fat loss and muscle preservation.
Medical Disclaimer: This content is for educational purposes only. Multi-peptide stacks are advanced protocols. Always consult a qualified healthcare provider before starting any peptide protocol. Full disclaimer →
Why These Peptides Work Together
Semaglutide and Ipamorelin/CJC-1295 address body recomposition through complementary mechanisms. Semaglutide drives significant fat loss through appetite suppression and metabolic improvement. Ipamorelin/CJC-1295 stimulates GH and IGF-1, which preserves and builds lean muscle mass during the caloric deficit created by Semaglutide. The combination addresses the primary limitation of GLP-1 therapy — muscle mass loss — by maintaining anabolic signaling throughout the fat loss phase.
Protocol Overview
This is an advanced protocol requiring physician supervision due to the prescription nature of Semaglutide. Semaglutide is titrated per standard protocol (starting at 0.25 mg/week). Ipamorelin/CJC-1295 is added at standard doses (200–300 mcg before bed). Resistance training is essential to maximize the muscle-preserving effects of GH stimulation.
Dosing Schedule
| Peptide | Dose | Timing | Route |
|---|---|---|---|
| Semaglutide | 0.25–2.4 mg | Once weekly | Subcutaneous (prescription) |
| Ipamorelin/CJC-1295 | 200–300 mcg / 100 mcg | Before bed, 5–7 days/week | Subcutaneous |
✓ Who This Stack Is For
Adults seeking significant body recomposition who want to maximize fat loss while preserving or building lean muscle mass. Requires physician supervision due to Semaglutide prescription requirement.
Evidence Base
Both components have strong evidence bases individually. The combination is used in functional medicine and anti-aging practices, though no specific combination trials have been conducted.
Frequently Asked Questions
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