Wegovy vs Saxenda: Which GLP-1 Obesity Drug Is More Effective?
Verdict Summary
Wegovy (semaglutide 2.4mg) produces significantly greater weight loss (~15% vs ~8%) and requires only once-weekly dosing. Saxenda (liraglutide) has a longer obesity-specific track record.
Medical Disclaimer: This comparison is for educational purposes only. Consult a healthcare provider before starting any peptide protocol. Full disclaimer →
At a Glance
| Dimension | Wegovy | Saxenda |
|---|---|---|
| Active Compound | Semaglutide 2.4mg | Liraglutide 3mg |
| Dosing | Once weekly | Once daily |
| Avg. Weight Loss | ~15% | ~8% |
| FDA Obesity Approval | 2021 | 2014 |
Wegovy Deep Dive
Wegovy's once-weekly dosing and superior efficacy have made it the preferred GLP-1 for obesity in most clinical guidelines. The STEP 8 trial directly comparing semaglutide to liraglutide showed semaglutide's clear superiority.
How to Choose
Choose Wegovy if…
- •You want the most effective GLP-1 option
- •Weekly dosing is convenient for your lifestyle
- •Cost per unit of weight loss is a consideration
Choose Saxenda if…
- •Daily dosing flexibility is preferred
- •You have had adverse reactions to semaglutide
- •Saxenda is covered by your insurance and Wegovy is not
Frequently Asked Questions
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